Interesting question. Just to rephrase the question, are you asking "how can I expect my body composition of a random individual to change when taking incretin product X for duration Y?" There is extensive longitudinal measurements of aggregative weight change, muscle change, and fat change while taking these products in comparison to a placebo. This is the core of their published clinical studies. Some of this is summarized in a review paper from Kevin Hall as well. https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.24027
However, I'm not familiar with any tools specifically designed to approximate results for an individual patient. That could be an interesting tool to make!
I mean more like a pharmacological model. Something that may be able to be used to visualize the effects. A 3D or advanced digital model. I am looking for these tools around the industry. Not clinical data but could have come from clinical data.
The weight loss drugs that suppress appetite don't address one of the major contributors to weight gain, which is eating from stress or boredom. I think that for any weight loss drug to be really effective, regardless of its mechanism of action, it would have to be accompanied by at least a little cognitive therapy so people substitute mindfulness for mindless grazing. You're bored before bedtime and it's easy to start snacking. Recognizing why you reach for the chips can help you redirect and form a new, more constructive response. If you're going to get off the couch and walk into the kitchen, why not walk the other way, instead, and do something productive? Everyone defines productivity differently, but as long as it doesn't include eating more you'll probably make more weight loss progress than with drugs alone or in combination.
It seems like the satiating effect of these drugs does help with the stress and boredom eating. At least from what I have heard anecdotally. But, to your same point, how much of these drugs benefit could be achieved by making better night time habits? Probably a good chunk.
A hundred percent, in my case. In my early 30's I tried a couple of different OTC appetite suppressants, but the problem wasn't that I ate too much when I was hungry. It was that I ate too much when I wasn't hungry. The only real, lasting success I had was in my 40's when I measured food, counted calories, and ran 50 miles per week. The keto diet's good, too, if you don't pretend that bread made with coconut flour is bread.
Also, what I should have mentioned is that people who have bariatric surgery and regain the weight they lose support the idea that a big part of the problem is psychological. I think they're supposed to be offered counseling before and after the surgery, but if that doesn't take then the surgery has less chance of being a permanent fix.
Not in pharmacology ever since working in Life Zciences. I am interested in if there are tools for modeling efficacy.
Interesting question. Just to rephrase the question, are you asking "how can I expect my body composition of a random individual to change when taking incretin product X for duration Y?" There is extensive longitudinal measurements of aggregative weight change, muscle change, and fat change while taking these products in comparison to a placebo. This is the core of their published clinical studies. Some of this is summarized in a review paper from Kevin Hall as well. https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.24027
However, I'm not familiar with any tools specifically designed to approximate results for an individual patient. That could be an interesting tool to make!
I mean more like a pharmacological model. Something that may be able to be used to visualize the effects. A 3D or advanced digital model. I am looking for these tools around the industry. Not clinical data but could have come from clinical data.
The weight loss drugs that suppress appetite don't address one of the major contributors to weight gain, which is eating from stress or boredom. I think that for any weight loss drug to be really effective, regardless of its mechanism of action, it would have to be accompanied by at least a little cognitive therapy so people substitute mindfulness for mindless grazing. You're bored before bedtime and it's easy to start snacking. Recognizing why you reach for the chips can help you redirect and form a new, more constructive response. If you're going to get off the couch and walk into the kitchen, why not walk the other way, instead, and do something productive? Everyone defines productivity differently, but as long as it doesn't include eating more you'll probably make more weight loss progress than with drugs alone or in combination.
It seems like the satiating effect of these drugs does help with the stress and boredom eating. At least from what I have heard anecdotally. But, to your same point, how much of these drugs benefit could be achieved by making better night time habits? Probably a good chunk.
A hundred percent, in my case. In my early 30's I tried a couple of different OTC appetite suppressants, but the problem wasn't that I ate too much when I was hungry. It was that I ate too much when I wasn't hungry. The only real, lasting success I had was in my 40's when I measured food, counted calories, and ran 50 miles per week. The keto diet's good, too, if you don't pretend that bread made with coconut flour is bread.
Also, what I should have mentioned is that people who have bariatric surgery and regain the weight they lose support the idea that a big part of the problem is psychological. I think they're supposed to be offered counseling before and after the surgery, but if that doesn't take then the surgery has less chance of being a permanent fix.
Are there any prominent ai companies that have successfully modelled ozempic out there?
Can you be more specific about your question? Do you mean the protein structure?