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Fager 132's avatar

That sounds like stem cell therapy. It must have a different mechanism of action, though, because the ortho surgeon I saw about my rotator cuffs didn't mention stem cells. Maybe he wasn't familiar with peptide treatments, or not willing to risk using something without human trials evidence behind it. I'd have done the surgery just because I associate surgery with awesome drugs, but the recovery period is insane. No fleeting post-anesthesia high is worth that.

David Kingsley, PhD's avatar

I’d love for one of these ortho centers to publish recovery times following surgery for patients who supplement BPC-157 vs control. It’s not a perfect double-blinded placebo controlled study, but if it’s as impactful as the anecdotal evidence claims, there should be a signal.

Owen Lewis's avatar

What do you think of peptides overall?

David Kingsley, PhD's avatar

I’d break my feelings into 3 parts —

I) Incretin-based peptides, e.g., semaglutide, tirzepatide, retatrutide, etc, these are blockbuster drugs that are reshaping health. Extremely bullish. 10/10.

II) Wellness Peptides, e.g., BPC-157 and others. Even these I’m a bit mixed. The best seem to have real potential and be well tolerated. For instance, Semax has been used for decades in eastern Europe. Category 2 was indefensible. The biggest imo is related to CMC. If the manufacturing and analytics are well done, there seems to be little down side and large upside. I plan to experiment here. Cautiously optimistic.