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Nathan Slake's avatar

Wow, bumper crop of stories and info here David. Thanks.

This is wild: "This isn't a minor improvement—it boosted the survival rates of edited mouse embryos by an incredible 800%, suggesting that extensive, precise genetic edits might soon become feasible at scale."

Also, huge thanks for the PNAS paper. That one is going straight to some of my students who have just been learning about amino acids and the original Miller-Urey experiment.

David Kingsley, PhD's avatar

Hey Nathan. I was quite behind on some of these updates but had been doing them little by little. So in the end, it was quite the haul!

The multiplex editing is the real deal and is already here. It's quite eye opening what it means.

I had a feeling you'd like the Miller-Urey experiment. I hope your students find it interesting as well.

I haven't had a ton of time to read recently. There has been trouble in paradise, but I'm hoping to catch up in the near future on some of yours.

Nathan Slake's avatar

Never any hurry, mate, or any worries if you don't get to any.

Hope all is ok!

Based If True's avatar

Would you rather fight 100 mouse sized Wolly Mammoths, or 1 Wolly mammoth sized mouse?

David Kingsley, PhD's avatar

Apparently, 'wolly' is the slang term for pickled cucumber in the UK. I would pick the latter, but I want the woolly mammoth-sized mouse to still have the coat of a woolly mouse.

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Mar 19, 2025
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David Kingsley, PhD's avatar

This is the second such approved drug I've found to be a bit of a head scratcher in the last year. The common theme is being tremendously expensive for terminal diseases without showing much benefit.