Convenience is the only way to get people to care about their health. As unfortunate as this is, at least we'll have a supplement for those who truly can't exercise or have some other condition that prevents them from either sleeping or exercising.
Thanks for engaging! I think there are a lot of people who spend enormous effort working on their health despite how the inconvenience. I do agree though that any chance we have to reduce friction (or general barriers to entry) for a new behavior, we will see more wider spread adoption and compliance. This is obviously extremely important for the healthcare system we all are a part of.
The biggest issue is the salvage pathway which gets reduced with age but does increase with exercise. In addition, the increase of CD38 as we age depletes NAD+ as we age, so taking in Apigenin and Quercetin helps fill those receptors instead of NAD+.
I agree, exercise (and proper sleep) seem to be the only natural remedies we can really do to help with pretty much everything. Unfortunately, those are the two things that seem to go by the wayside when we are stressed.
I am less familiar with apigenin and quercetin, but after a quick google search they both look promising. While the mechanism seems to make sense, I am more skeptical about our ability to harness it treat humans, e.g.,, proper Q/A, formulation, dosing studies, etc. But perhaps these are being or have been studied. Similar thoughts for B3.
Are you less excited about NAD+ precursor supplements through NMN like MIB-626?
My question was going to be about whether we are always getting enough B3 in our diet anyway to make taking supplements irrelevant, but then you covered that 😆
Re: consistent levels of NADH ... I'd need to do some reading but I assume the body usually keeps these levels low regardless, because at least in metabolism any oxidation of fuels would mean the reduced form of NADH that is generated has its electrons very rapidly handed off to the electron transport chain and becomes oxidised back to NAD+. So even if NAD+ levels are high, there's never going to be as much NADH in the steady state. Could be all many of things changing with ageing, though. Interesting topic for sure. A shame that much like with all supplements (and pharmaceuticals in general), there's likely $$$ profit to be had irrespective of the science 😞
Thanks, Nathan! I think our minds are in a similar space here. The issue of self-inflicted illnesses due to poor nutrition is a significant concern, especially in countries like the US where processed foods are so prevalent. However, it seems this is becoming a global issue. I've been thinking a lot more about how these issues extend well beyond the individual, particularly in countries with socialized medicine.
I think you're right here. In the figure above, NADH is kept fairly consistent in serum (20ish ng/mL) throughout life where NAD+ goes from roughly 60ng/mL to approximately 10.
I agree, that the financial interests are enormous and often improperly aligned with what we actually want as an outcome. While I can somewhat sympathize with pharmaceutical companies due to the high costs of research, development, and clinical trials, the supplement industry operates in a much less regulated space. Even without the FDA, it would be great to see internal market forces create validation bodies so we can be confident in what we are purchasing.
Convenience is the only way to get people to care about their health. As unfortunate as this is, at least we'll have a supplement for those who truly can't exercise or have some other condition that prevents them from either sleeping or exercising.
Thanks for engaging! I think there are a lot of people who spend enormous effort working on their health despite how the inconvenience. I do agree though that any chance we have to reduce friction (or general barriers to entry) for a new behavior, we will see more wider spread adoption and compliance. This is obviously extremely important for the healthcare system we all are a part of.
The biggest issue is the salvage pathway which gets reduced with age but does increase with exercise. In addition, the increase of CD38 as we age depletes NAD+ as we age, so taking in Apigenin and Quercetin helps fill those receptors instead of NAD+.
The form of B3 does matter as well.
I agree, exercise (and proper sleep) seem to be the only natural remedies we can really do to help with pretty much everything. Unfortunately, those are the two things that seem to go by the wayside when we are stressed.
I am less familiar with apigenin and quercetin, but after a quick google search they both look promising. While the mechanism seems to make sense, I am more skeptical about our ability to harness it treat humans, e.g.,, proper Q/A, formulation, dosing studies, etc. But perhaps these are being or have been studied. Similar thoughts for B3.
Are you less excited about NAD+ precursor supplements through NMN like MIB-626?
Good read and info, David, thanks as always.
My question was going to be about whether we are always getting enough B3 in our diet anyway to make taking supplements irrelevant, but then you covered that 😆
Re: consistent levels of NADH ... I'd need to do some reading but I assume the body usually keeps these levels low regardless, because at least in metabolism any oxidation of fuels would mean the reduced form of NADH that is generated has its electrons very rapidly handed off to the electron transport chain and becomes oxidised back to NAD+. So even if NAD+ levels are high, there's never going to be as much NADH in the steady state. Could be all many of things changing with ageing, though. Interesting topic for sure. A shame that much like with all supplements (and pharmaceuticals in general), there's likely $$$ profit to be had irrespective of the science 😞
Thanks, Nathan! I think our minds are in a similar space here. The issue of self-inflicted illnesses due to poor nutrition is a significant concern, especially in countries like the US where processed foods are so prevalent. However, it seems this is becoming a global issue. I've been thinking a lot more about how these issues extend well beyond the individual, particularly in countries with socialized medicine.
I think you're right here. In the figure above, NADH is kept fairly consistent in serum (20ish ng/mL) throughout life where NAD+ goes from roughly 60ng/mL to approximately 10.
I agree, that the financial interests are enormous and often improperly aligned with what we actually want as an outcome. While I can somewhat sympathize with pharmaceutical companies due to the high costs of research, development, and clinical trials, the supplement industry operates in a much less regulated space. Even without the FDA, it would be great to see internal market forces create validation bodies so we can be confident in what we are purchasing.